{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314869/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314869"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Potential of an in vitro mouse testicular organ culture system as a platform for mechanism-based evaluation of testicular toxicity","description":"This study examined testicular toxicity induced by methoxyacetic acid (MAA) using an in vitro mouse testicular organ culture system. Testis tissues were cultured for 4 weeks and then exposed to MAA (1–4 mM) for 24 hours. Higher MAA concentrations reduced germ-cell viability and spermatocyte populations, accompanied by increased apoptosis. RNA-seq analysis revealed early transcriptional perturbations at 1 mM and broad suppression of cell-cycle and meiotic pathways at 4 mM. These findings characterize dose-dependent molecular and cellular changes associated with MAA-induced testicular toxicity.","dates":{"publication":"2026/05/12"},"accession":"GSE314869","cross_references":{"GSM":["GSM9414772","GSM9414771","GSM9414770","GSM9414776","GSM9414765","GSM9414775","GSM9414764","GSM9414763","GSM9414773","GSM9414762","GSM9414769","GSM9414779","GSM9414768","GSM9414778","GSM9414767","GSM9414766","GSM9414777"],"GPL":["34290"],"GSE":["314869"],"taxon":["Mus musculus"],"PMID":["[41903202]"]}}