{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314981"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Microarray analysis of quadriceps muscle of fed or 24 h-fasted wild type mice and skeletal muscle-specific FoxO1,3,4 knockout mice","description":"Catabolic conditions, such as starvation, inactivity, and cancer cachexia, induce Forkhead box O (FoxO) transcription factor(s) expression and severe muscle atrophy via the induction of ubiquitin–proteasome system-mediated muscle proteolysis, resulting in frailty and poor quality of life. Microarray analysis of quadriceps muscle of fed or 24 h-fasted wild type mice and skeletal muscle-specific FoxO1,3,4 knockout mice identified the potential novel FoxOs-target genes in skeletal muscle including Redd1, Sestrin1, Castor2, Chac1, Depp1, Lat3, as well as Cebpd. This study comprehensively identifies novel potential FoxOs-target genes in skeletal muscle and clarifies the pathophysiological role of FoxOs, master regulators of skeletal muscle atrophy.","dates":{"publication":"2026/04/20"},"accession":"GSE314981","cross_references":{"GSM":["GSM9419757","GSM9419746","GSM9419745","GSM9419756","GSM9419759","GSM9419748","GSM9419747","GSM9419758","GSM9419753","GSM9419752","GSM9419744","GSM9419755","GSM9419754","GSM9419749","GSM9419751","GSM9419750"],"GPL":["13912"],"GSE":["314981"],"taxon":["Mus musculus"]}}