{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315007/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315007"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Sex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice.","description":"Most western diets or Amilyn-based diets induce MASLD and MASH in mice but do not fully reproduce metabolic dysfunction in male and female mice. In this study, a high fat diet containing cholesterol (D12120101, Research Diets, Inc) supplemented with 10% w/v fructose in the drinking water (HFC+Fr diet) was provided to control and hepatocyte specific Pparg knockout male and female mice for 24 weeks. Both HFC+Fr-fed male and female mice developed obesity and insulin resistance. Only male mice developed clear signs of MASH with fibrosis. Hepatocyte specific Pparg had a significant effect in the regulation of hepatic transcriptomics in HFC+Fr-fed male mice.","dates":{"publication":"2026/04/06"},"accession":"GSE315007","cross_references":{"GSM":["GSM9420039","GSM9420038","GSM9420037","GSM9420036","GSM9420035","GSM9420034","GSM9420056","GSM9420055","GSM9420033","GSM9420032","GSM9420054","GSM9420031","GSM9420053","GSM9420052","GSM9420030","GSM9420051","GSM9420050","GSM9420029","GSM9420028","GSM9420049","GSM9420027","GSM9420048","GSM9420047","GSM9420046","GSM9420045","GSM9420044","GSM9420043","GSM9420042","GSM9420041","GSM9420040"],"GPL":["34290"],"GSE":["315007"],"taxon":["Mus musculus"],"PMID":["[41889940]"]}}