GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315007/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315007GEOGSEfalseSex- and hepatocyte Pparg-dependent hepatic effects of a high fat diet containing 60% kcal from fat and 2% cholesterol, which was supplemented with 10% fructose in the drinking water (HFC+Fr) to induce diet-induced obesity in male and female mice.Most western diets or Amilyn-based diets induce MASLD and MASH in mice but do not fully reproduce metabolic dysfunction in male and female mice. In this study, a high fat diet containing cholesterol (D12120101, Research Diets, Inc) supplemented with 10% w/v fructose in the drinking water (HFC+Fr diet) was provided to control and hepatocyte specific Pparg knockout male and female mice for 24 weeks. Both HFC+Fr-fed male and female mice developed obesity and insulin resistance. Only male mice developed clear signs of MASH with fibrosis. Hepatocyte specific Pparg had a significant effect in the regulation of hepatic transcriptomics in HFC+Fr-fed male mice.2026/04/06GSE315007GSM9420039GSM9420038GSM9420037GSM9420036GSM9420035GSM9420034GSM9420056GSM9420055GSM9420033GSM9420032GSM9420054GSM9420031GSM9420053GSM9420052GSM9420030GSM9420051GSM9420050GSM9420029GSM9420028GSM9420049GSM9420027GSM9420048GSM9420047GSM9420046GSM9420045GSM9420044GSM9420043GSM9420042GSM9420041GSM942004034290315007Mus musculus[41889940]