{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315144/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315144"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Artificial intelligence-guided single-cell transcriptomic analysis for identifying O-GlcNAc transferase in fibroblast-like synoviocytes as a therapeutic target for rheumatoid arthritis","description":"Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation, synovial hyperplasia, and the destruction of bone and cartilage. Despite the use of various immunosuppressive disease-modifying antirheumatic drugs (DMARDs), a considerable proportion of RA patients remain symptomatic. As RA progresses, fibroblast-like synoviocytes (FLSs) undergo a phenotypic transition to an aggressive state, making them attractive non-immune cellular targets for RA treatment. However, there are currently no clinically available therapies that selectively ablate RA-FLSs due to the lack of specific molecular targets. Our research focuses on the knockdown of the OGT and SAP130 genes in RA-FLSs. OGT and SAP130 are expressed in the cell of RA-FLSs and plays a crucial role in their aggressive transition. By specific knockout of OGT and SAP130 we observed a significant supression of aggressive transformations of RA-FLS.","dates":{"publication":"2026/09/01"},"accession":"GSE315144","cross_references":{"GSM":["GSM9422110","GSM9422111","GSM9422112","GSM9422113","GSM9422114","GSM9422115","GSM9422116","GSM9422106","GSM9422117","GSM9422118","GSM9422107","GSM9422108","GSM9422119","GSM9422109"],"GPL":["18460"],"GSE":["315144"],"taxon":["Homo sapiens"]}}