{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315295/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"," Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315295"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Distinct nociceptor roles in inflammation and itch revealed by subset-specific transcriptomic adaptation","description":"This study identifies two distinct subsets of sensory neurons that separately regulate itch and inflammation in allergic contact dermatitis. MrgprD⁺ nonpeptidergic neurons adopt a transient regenerative program during inflammation and are essential for itch behavior, while Trpv1⁺ peptidergic neurons limit inflammation by restraining neutrophil infiltration. These findings uncover parallel, nonredundant neuronal circuits that independently control inflammatory and pruritic responses in the skin.","dates":{"publication":"2026/04/15"},"accession":"GSE315295","cross_references":{"GSM":["GSM9424609","GSM9424608","GSM9424619","GSM9424610","GSM9424612","GSM9424611","GSM9424603","GSM9424614","GSM9424613","GSM9424602","GSM9424616","GSM9424605","GSM9424604","GSM9424615","GSM9424618","GSM9424607","GSM9424606","GSM9424617"],"GPL":["33762"],"GSE":["315295"],"taxon":["Mus musculus"," Homo sapiens"]}}