GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315295/primaryOK200Other Mus musculusHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315295GEOGSEfalseDistinct nociceptor roles in inflammation and itch revealed by subset-specific transcriptomic adaptationThis study identifies two distinct subsets of sensory neurons that separately regulate itch and inflammation in allergic contact dermatitis. MrgprD⁺ nonpeptidergic neurons adopt a transient regenerative program during inflammation and are essential for itch behavior, while Trpv1⁺ peptidergic neurons limit inflammation by restraining neutrophil infiltration. These findings uncover parallel, nonredundant neuronal circuits that independently control inflammatory and pruritic responses in the skin.2026/04/15GSE315295GSM9424609GSM9424608GSM9424619GSM9424610GSM9424612GSM9424611GSM9424603GSM9424614GSM9424602GSM9424613GSM9424616GSM9424605GSM9424604GSM9424615GSM9424618GSM9424607GSM9424606GSM942461733762315295 Mus musculusHomo sapiens