{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315336/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315336"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Compartment specific mitochondrial unfolded protein response","description":"Alzheimer’s disease lacks effective disease‑modifying treatments partly because early, compartment‑specific mitochondrial stress responses in microglia remain poorly defined. Our findings show that APP expression and targeted activation of UPRmt-MM or UPRmt-IMS produce distinct transcriptional signatures—ranging from immune activation and impaired oxidative phosphorylation to disrupted mitochondrial ribosome integrity—highlighting mitochondrial compartmentalization as a key driver of AD pathogenesis and a potential therapeutic target.","dates":{"publication":"2026/09/09"},"accession":"GSE315336","cross_references":{"GSM":["GSM9425570","GSM9425572","GSM9425561","GSM9425560","GSM9425571","GSM9425563","GSM9425574","GSM9425562","GSM9425573","GSM9425565","GSM9425564","GSM9425567","GSM9425566","GSM9425569","GSM9425568","GSM9425559"],"GPL":["11154"],"GSE":["315336"],"taxon":["Homo sapiens"],"PMID":["[42694256]"]}}