GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315336/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315336GEOGSEfalseCompartment specific mitochondrial unfolded protein responseAlzheimer’s disease lacks effective disease‑modifying treatments partly because early, compartment‑specific mitochondrial stress responses in microglia remain poorly defined. Our findings show that APP expression and targeted activation of UPRmt-MM or UPRmt-IMS produce distinct transcriptional signatures—ranging from immune activation and impaired oxidative phosphorylation to disrupted mitochondrial ribosome integrity—highlighting mitochondrial compartmentalization as a key driver of AD pathogenesis and a potential therapeutic target.2026/09/09GSE315336GSM9425570GSM9425572GSM9425561GSM9425560GSM9425571GSM9425563GSM9425574GSM9425562GSM9425573GSM9425565GSM9425564GSM9425567GSM9425566GSM9425569GSM9425568GSM942555911154315336Homo sapiens[42694256]