{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315356/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315356"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq technique to identify key differentially expressed genes in hepatocytes of HFD-treated Lyve1-Cre;Heg1fl/fl mice.","description":"Heart-of-glass (Heg) is a type I transmembrane protein. Previous studies have demonstrated that knockout of the Heg1 gene in mouse liver endothelial cells disrupts hepatic metabolic zonation by downregulating Wnt ligands in endothelial cells. To further investigate the metabolic changes in hepatocytes, alterations in Wnt receptor genes, and other potential genetic changes following endothelial-specific Heg1 knockout in mice with hepatic steatosis, this study was conducted.","dates":{"publication":"2026/06/18"},"accession":"GSE315356","cross_references":{"GSM":["GSM9426139","GSM9426138","GSM9426140","GSM9426142","GSM9426141"],"GPL":["24247"],"GSE":["315356"],"taxon":["Mus musculus"],"PMID":["[42119921]"]}}