{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315391/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Aplysia californica"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315391"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Aplysia Pleural Ganglia 7 Days After Long-Term Sensitization Training.","description":"We used a custom-designed microarray to characterize the transcriptional response that persists 5 days after long-term sensitization training in the marine mollusk Aplysia californica, a time-point at which recall has partially decayed but there is still clear sensitization memory expressed in most animals. Aplysia were exposed to a 1-day unilateral LTS training protocol (4 rounds of noxious shock at 30 min intervals, each shock 10s of 1/2s off 1/2on 90mA 60-hz biphasic square-wave shock). Duration of the tail-elicited siphon withdrawal reflex was measured before training, 1 day after training, and 5 days after training. From the 1-day post-tests we selected 32 animals showing strong sensitization responses (at least 30% increase in reflex duration on the side of training). At the 5-day post-test we observed substantial but not complete decay of the expresison of sensitizaiton. Plueral ganglia were harvested immediately after the 5-day post tests for microarray analysis; these ganglia contain the VC nociceptors known to help encode sensitization memory. Samples from a left-trained and right-trained animal were combined to smooth out lateralized gene expression (32 animals produced 16 microarray samples, each having a set of trained plueral ganglia and a set of untrained plueral ganglia). In addition, within each batch of animals collected we matched the highest-forgetting left-trained animal with the highest-forgetting right-trained animal, and so on, producing samples consistent in levels of forgetting and considerable diversity in forgetting across samples.","dates":{"publication":"2026/04/15"},"accession":"GSE315391","cross_references":{"GSM":["GSM9426640","GSM9426630","GSM9426641","GSM9426633","GSM9426644","GSM9426634","GSM9426631","GSM9426642","GSM9426643","GSM9426632","GSM9426637","GSM9426638","GSM9426635","GSM9426636","GSM9426639","GSM9426629"],"GPL":["18666"],"GSE":["315391"],"taxon":["Aplysia californica"],"PMID":["[41802864]"]}}