GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315408/primaryOK200Other synthetic constructHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315408GEOGSEfalseSpatial and single-nucleus multi-omics profiling reveals heterogeneous endothelial cell overabundance in endocardial fibroelastosis [MERFISH]Endocardial fibroelastosis (EFE) is a lethal fibrotic complication that affects up to 70% of patients with hypoplastic left heart syndrome (HLHS). The absence of effective therapies for EFE stems from a fundamental lack of understanding of its underlying cellular and molecular mechanisms. Progress in investigating EFE pathogenesis has been further constrained by the scarcity of patient-derived samples. Our study directly addresses this critical knowledge gap by performing an integrative multi-omics study—combining single-nucleus RNA/ATAC sequencing and high-resolution spatial transcriptomics (MERFISH) on human EFE and healthy heart tissues.2026/08/29GSE315408GSM9427139GSM9427137GSM9427138GSM9427140GSM942714131217315408 synthetic constructHomo sapiens