{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315421/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315421"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"In vivo antimicrobial therapeutic efficacy and immune homeostasis analysis of S. aureus peritonitis","description":"Type-I photosensitization addresses the dilemma of intracellular bacterial hypoxia-induced photodynamic therapeutic (PDT) inefficacy, yet precise targeting and eradicating sequestered pathogens remains a formidable challenge. Herein, we engineer an albumin-based photodynamic conversion nanomedicine integrating target-specific recognition with controlled antibacterial functions to precisely eliminate intracellular pathogens and restore infected cell activity. Mechanistic studies reveal a vertically-crossed conformation that promotes intramolecular electron transfer and charge separation, redirecting photosensitizer (PS) reactivity toward type-I reactive oxygen species (ROS) generation. Electron-rich albumin further enhances cationic PS+• recycling, photostability and O2-• generation, while minimizing off-target organelle effects. We demonstrate application in S. aureus-infected sepsis showing high type-I ROS levels for antibacterial function from the nanomedicine to restore redox and immune homeostasis without noticeable toxicity. This work pioneers a strategy to convert ROS generation from type-II to type-I pathways for hypoxia-tolerant bacterial elimination, merging mechanistic precision with translational potential for clinical sepsis management.","dates":{"publication":"2026/05/01"},"accession":"GSE315421","cross_references":{"GSM":["GSM9427844","GSM9427847","GSM9427848","GSM9427845","GSM9427846","GSM9427849"],"GPL":["19057"],"GSE":["315421"],"taxon":["Mus musculus"]}}