{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315571/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315571"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RXR binding pattern in human PMA-differentiated THP-1 cells upon ligand stimulation [ChIP-seq]","description":"Retinoid X receptors (RXRs) act as obligate dimerisation partners for multiple nuclear receptors (NRs), each with distinct regulatory functions. In this study, human PMA-differentiated THP-1 (PMA-THP-1) cells were treated with single or combined ligands for RXR or six partners for 2 hours, and the genomic binding landscape of RXR was investigated using ChIP-seq. RXR genomic binding regions were also mapped following 1 hour of treatment with vehicle or 1,25-vitD using ChIP-seq. In addition, histone H3 lysine 27 acetylation (H3K27ac) was mapped following 6 hours of treatment with vehicle or 1,25-vitD using ChIP-seq. In parallel, RNA-seq was performed on PMA-THP-1 cells following 6 hours of treatment with vehicle, 1,25-vitD or combined ligands to identify and compare the regulated gene sets.","dates":{"publication":"2026/05/14"},"accession":"GSE315571","cross_references":{"GSM":["GSM9431769","GSM9431755","GSM9431777","GSM9431754","GSM9431776","GSM9431757","GSM9431779","GSM9431778","GSM9431756","GSM9431772","GSM9431775","GSM9431774","GSM9431771","GSM9431770","GSM9431758","GSM9431765","GSM9431768","GSM9431767","GSM9431784","GSM9431762","GSM9431761","GSM9431783","GSM9431764","GSM9431785","GSM9431763","GSM9431760","GSM9431782","GSM9431781"],"GPL":["30173"],"GSE":["315571"],"taxon":["Homo sapiens"],"PMID":["[42031173]"]}}