GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315571/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315571GEOGSEfalseRXR binding pattern in human PMA-differentiated THP-1 cells upon ligand stimulation [ChIP-seq]Retinoid X receptors (RXRs) act as obligate dimerisation partners for multiple nuclear receptors (NRs), each with distinct regulatory functions. In this study, human PMA-differentiated THP-1 (PMA-THP-1) cells were treated with single or combined ligands for RXR or six partners for 2 hours, and the genomic binding landscape of RXR was investigated using ChIP-seq. RXR genomic binding regions were also mapped following 1 hour of treatment with vehicle or 1,25-vitD using ChIP-seq. In addition, histone H3 lysine 27 acetylation (H3K27ac) was mapped following 6 hours of treatment with vehicle or 1,25-vitD using ChIP-seq. In parallel, RNA-seq was performed on PMA-THP-1 cells following 6 hours of treatment with vehicle, 1,25-vitD or combined ligands to identify and compare the regulated gene sets.2026/05/14GSE315571GSM9431769GSM9431755GSM9431777GSM9431754GSM9431776GSM9431757GSM9431779GSM9431778GSM9431756GSM9431772GSM9431775GSM9431774GSM9431771GSM9431770GSM9431758GSM9431765GSM9431768GSM9431767GSM9431784GSM9431762GSM9431761GSM9431783GSM9431764GSM9431763GSM9431785GSM9431760GSM9431782GSM943178130173315571Homo sapiens[42031173]