GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315637/primaryOK200TranscriptomicsMus musculus OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315637GEOGSEfalseImmunopeptidome profiling in pulmonary fibrosis provides a new platform for identifying therapeutic targetsFibrosis is the common and final pathological outcome of many chronic diseases and is a significant unmet medical need. Changes in the peptide profile presented by major histocompatibility complex class I molecules (MHC-I) are important pathological signals in diseases. The identification of "new antigens" in fibrosis potentially helps understand the pathogenesis and the therapeutic target. Here, we show that characterizing the MHC-I immunopeptidome of pulmonary fibrosis tissues identifies a series of pathological MHC-I ligands, leading to the discovery of multiple "fibrosis-associated antigens (FAAs)". Notably, three MHC-I peptides from Tns3, Apbb2, and Maf effectively block pulmonary fibrosis progression when used as a therapeutic vaccine. This study shows that profiling the immunopeptidome in fibrotic disease provides a promising platform for identifying therapeutic targets.2026/05/07GSE315637GSM9433608GSM9433619GSM9433609GSM9433617GSM9433618GSM9433607GSM9433615GSM9433616GSM9433613GSM9433614GSM9433622GSM9433611GSM9433612GSM9433620GSM9433621GSM94336102424734290315637Mus musculus[42010059]