GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315950/primaryOK200TranscriptomicsCaenorhabditis elegansExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315950GEOGSEfalselet-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC1]We examined gene expression changes using mRNA-seq in two different lin-28 mutant strains, lin-28(n719) and lin-28(xe192). Although both are considered genetic null mutants, their expression profiles differ substantially: lin-28(n719) (a point mutation affecting a splice site) shows many more dysregulated genes than lin-28(xe192) (a deletion of the entire lin-28 locus).2026/06/10GSE315950GSM9440850GSM9440854GSM9440853GSM9440852GSM9440851GSM9440847GSM9440858GSM9440857GSM9440846GSM9440845GSM9440856GSM9440855GSM9440844GSM9440849GSM9440848GSM944085926672315950Caenorhabditis elegans