{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316022"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells","description":"BCL11A is a transcription factor crucial for neurodevelopment and hematopoiesis. It regulates the developmental switch from fetal hemoglobin (HbF) to adult hemoglobin and is a major therapeutic target for sickle cell disease and b-thalassemia. We investigated BCL11A functions in human erythrocyte precursor HUDEP-2 cells. We treated HUDEP-2 cells (which normally express adult hemoglobin) with inhibitors targeting epigenetic silencing marks - DNA methylation and histone H3 lysine 27 methylation. All treatments, individually or in combination, increased HbF expression to varying degrees.","dates":{"publication":"2026/04/14"},"accession":"GSE316022","cross_references":{"GSM":["GSM9443391","GSM9443392","GSM9443393","GSM9443394"],"GPL":["34284"],"GSE":["316022"],"taxon":["Homo sapiens"],"PMID":["[41822826]"]}}