GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316022/primaryOK200Methylation profilingHomo sapiensMethylation profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316022GEOGSEfalseRegulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cellsBCL11A is a transcription factor crucial for neurodevelopment and hematopoiesis. It regulates the developmental switch from fetal hemoglobin (HbF) to adult hemoglobin and is a major therapeutic target for sickle cell disease and b-thalassemia. We investigated BCL11A functions in human erythrocyte precursor HUDEP-2 cells. We treated HUDEP-2 cells (which normally express adult hemoglobin) with inhibitors targeting epigenetic silencing marks - DNA methylation and histone H3 lysine 27 methylation. All treatments, individually or in combination, increased HbF expression to varying degrees.2026/04/14GSE316022GSM9443391GSM9443392GSM9443393GSM944339434284316022Homo sapiens[41822826]