{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316091/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316091"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Long-term effects of adolescent risperidone treatment on mouse cortex","description":"Antipsychotics have been increasingly prescribed for children and adolescents. Despite multiple rodent studies showing long-term neurocognitive dysfunction associated with adolescent antipsychotic treatment, there is a lack of understanding of neurobiological underpinnings of these long-term changes. We utilized single nucleus RNA-seq to assess the long-term transcriptomic changes in mouse cortex, 9 weeks after they were treated with risperidone during adolescence. Analysis of the mouse cortex snRNA-seq dataset showed downregulation in voltage-gated and inwardly rectifying potassium channels and genes associated with synaptic structure and function in pyramidal neurons and interneurons. Our findings suggest that adolescent risperidone treatment can cause long-term transcriptomic changes associated with altered excitatory-inhibitory neuronal interactions.","dates":{"publication":"2026/07/14"},"accession":"GSE316091","cross_references":{"GSM":["GSM9444367","GSM9444364","GSM9444366","GSM9444365"],"GPL":["30172"],"GSE":["316091"],"taxon":["Mus musculus"],"PMID":["[42420423]"]}}