GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316091/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316091GEOGSEfalseLong-term effects of adolescent risperidone treatment on mouse cortexAntipsychotics have been increasingly prescribed for children and adolescents. Despite multiple rodent studies showing long-term neurocognitive dysfunction associated with adolescent antipsychotic treatment, there is a lack of understanding of neurobiological underpinnings of these long-term changes. We utilized single nucleus RNA-seq to assess the long-term transcriptomic changes in mouse cortex, 9 weeks after they were treated with risperidone during adolescence. Analysis of the mouse cortex snRNA-seq dataset showed downregulation in voltage-gated and inwardly rectifying potassium channels and genes associated with synaptic structure and function in pyramidal neurons and interneurons. Our findings suggest that adolescent risperidone treatment can cause long-term transcriptomic changes associated with altered excitatory-inhibitory neuronal interactions.2026/07/14GSE316091GSM9444367GSM9444364GSM9444366GSM944436530172316091Mus musculus[42420423]