{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316278/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316278"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacological Clearance of Senescent Cells Alleviates Bone Marrow Aging","description":"Aging of the hematopoietic system impairs HSC function and alters bone marrow niche behavior, increasing susceptibility to anemia, infections, and hematologic malignancies. Here, we employed the novel BCL-xL/BCL-2-targeted senolytic 753b to pharmacologically clear senescent cells in aged animals, evaluating its safety, efficacy, and restorative benefits to hematopoiesis.","dates":{"publication":"2026/09/25"},"accession":"GSE316278","cross_references":{"GSM":["GSM9448780","GSM9448787","GSM9448786","GSM9448785","GSM9448784","GSM9448783","GSM9448782","GSM9448781"],"GPL":["24247"],"GSE":["316278"],"taxon":["Mus musculus"],"PMID":["[42523366]"]}}