{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316290/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316290"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial and single-nucleus multi-omics profiling reveals heterogeneous endothelial cell overabundance in endocardial fibroelastosis [bulk RNA-seq]","description":"Endocardial fibroelastosis (EFE) is a lethal fibrotic complication that affects up to 70% of patients with hypoplastic left heart syndrome (HLHS). The absence of effective therapies for EFE stems from a fundamental lack of understanding of its underlying cellular and molecular mechanisms. Progress in investigating EFE pathogenesis has been further constrained by the scarcity of patient-derived samples. Our study directly addresses this critical knowledge gap by performing an integrative multi-omics study—combining single-nucleus RNA/ATAC sequencing and high-resolution spatial transcriptomics (MERFISH) on human EFE and healthy heart tissues.","dates":{"publication":"2026/08/31"},"accession":"GSE316290","cross_references":{"GSM":["GSM9448969","GSM9448976","GSM9448975","GSM9448974","GSM9448973","GSM9448972","GSM9448971","GSM9448970"],"GPL":["24676"],"GSE":["316290"],"taxon":["Homo sapiens"]}}