GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316290/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316290GEOGSEfalseSpatial and single-nucleus multi-omics profiling reveals heterogeneous endothelial cell overabundance in endocardial fibroelastosis [bulk RNA-seq]Endocardial fibroelastosis (EFE) is a lethal fibrotic complication that affects up to 70% of patients with hypoplastic left heart syndrome (HLHS). The absence of effective therapies for EFE stems from a fundamental lack of understanding of its underlying cellular and molecular mechanisms. Progress in investigating EFE pathogenesis has been further constrained by the scarcity of patient-derived samples. Our study directly addresses this critical knowledge gap by performing an integrative multi-omics study—combining single-nucleus RNA/ATAC sequencing and high-resolution spatial transcriptomics (MERFISH) on human EFE and healthy heart tissues.2026/08/31GSE316290GSM9448969GSM9448976GSM9448975GSM9448974GSM9448973GSM9448972GSM9448971GSM944897024676316290Homo sapiens