{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316440/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316440"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma [liver]","description":"To study the expression of epigenetic and metabolic genes in cholangiocarcinoma (CCA) tumor progression, CCA was induced in C57BL/6J mice by hydrodynamic tail vein injection (HTVI) of plasmids coding for Notch Intracellular Domain 1 (NICD1, 10 µg per mouse) in combination with myr-AKT (10 µg/mouse) and the sleeping beauty transposase (NICD1AKT). C57BL/6J mice without HTVI injection were used as healthy controls (C). Mice were sacrificed at 2 and 3 weeks to evaluate the expression landscape of epigenetic and metabolic genes in tumor progression. We then performed gene expression profiling using RNA-seq data from 3 mice per group.","dates":{"publication":"2026/06/25"},"accession":"GSE316440","cross_references":{"GSM":["GSM9453202","GSM9453203","GSM9453211","GSM9453212","GSM9453201","GSM9453206","GSM9453207","GSM9453204","GSM9453205","GSM9453208","GSM9453209","GSM9453210"],"GPL":["30172"],"GSE":["316440"],"taxon":["Mus musculus"],"PMID":["[42326014]"]}}