GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316440/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316440GEOGSEfalseTranscriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma [liver]To study the expression of epigenetic and metabolic genes in cholangiocarcinoma (CCA) tumor progression, CCA was induced in C57BL/6J mice by hydrodynamic tail vein injection (HTVI) of plasmids coding for Notch Intracellular Domain 1 (NICD1, 10 µg per mouse) in combination with myr-AKT (10 µg/mouse) and the sleeping beauty transposase (NICD1AKT). C57BL/6J mice without HTVI injection were used as healthy controls (C). Mice were sacrificed at 2 and 3 weeks to evaluate the expression landscape of epigenetic and metabolic genes in tumor progression. We then performed gene expression profiling using RNA-seq data from 3 mice per group.2026/06/25GSE316440GSM9453202GSM9453203GSM9453211GSM9453212GSM9453201GSM9453206GSM9453207GSM9453204GSM9453205GSM9453208GSM9453209GSM945321030172316440Mus musculus[42326014]