GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316563/primaryOK200TranscriptomicsMacaca mulattaExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316563GEOGSEfalseCaloric Restriction Reprograms Skeletal Muscle Molecular Pathways in Non-Human Primates: Potential Relevance to Human Aging BiologyTranscriptomic profiling revealed widespread gene expression differences between CR animals compared to controls. Genes that were overexpressed were mainly involved in pathways related to energy metabolism, mitochondrial function, signaling, and oxidative stress response. Conversely, underexpressed genes were connected to immune response, extracellular matrix organization, apoptosis, and ribosomal RNA processing. Further, we identify alternative splicing as a major mechanism by which caloric restriction modulates genes involved in muscle function, metabolism, and aging.2026/06/10GSE316563GSM9456092GSM9456093GSM9456094GSM9456095GSM9456090GSM9456091GSM9456119GSM9456115GSM9456116GSM9456117GSM9456118GSM9456111GSM9456112GSM9456113GSM9456114GSM9456096GSM9456097GSM9456098GSM9456099GSM9456110GSM9456083GSM9456084GSM9456108GSM9456109GSM9456104GSM9456105GSM9456106GSM9456107GSM9456100GSM9456122GSM9456089GSM9456101GSM9456102GSM9456103GSM9456085GSM9456086GSM9456120GSM9456087GSM9456088GSM945612127943316563Macaca mulatta[42104473]