{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316781/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316781"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Brown adipose tissue sustains thermogenesis through metabolic flexibility in glucose utilization","description":"To investigate the impact of dietary context on cold-activated brown adipose tissue (BAT) metabolism, we performed bulk RNA sequencing of BAT from 12-week old female mice fed a series of different diets after 1 week of cold exposure (6˚C; CE) or thermoneutral (28˚C; TN) housing. Diets included a normal chow diet (NCD; 13% fat per kcal, 25% protein per kcal, 62% carbohydrate per kcal) or a series of compositionally-matched diets including a low-fat diet (LFD; 10% fat per kcal, 20% protein per kcal, 70% carbohydrate per kcal), regular-fat diet (RFD; 20% fat per kcal, 20% protein per kcal, 60% carbohydrate per kcal), moderate-fat diet (MFD; 40% fat per kcal, 20% protein per kcal, 40% carbohydrate per kcal), high-fat diet (HFD; 60% fat per kcal, 20% protein per kcal, 20% carbohydrate per kcal), and very high-fat diet (VHFD; 72% fat per kcal, 20% protein per kcal, 8% carbohydrate per kcal). Mice were previously reared at room temperature (22-24˚C) and acclimated to each diet for 3 days before transitioning to temperature-controlled chambers.","dates":{"publication":"2026/09/03"},"accession":"GSE316781","cross_references":{"GSM":["GSM9460195","GSM9460173","GSM9460172","GSM9460194","GSM9460171","GSM9460193","GSM9460192","GSM9460170","GSM9460191","GSM9460190","GSM9460179","GSM9460178","GSM9460177","GSM9460176","GSM9460175","GSM9460174","GSM9460184","GSM9460183","GSM9460182","GSM9460181","GSM9460180","GSM9460169","GSM9460168","GSM9460189","GSM9460188","GSM9460187","GSM9460186","GSM9460185"],"GPL":["34290"],"GSE":["316781"],"taxon":["Mus musculus"]}}