GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317058/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317058GEOGSEfalseOverexpression of KLF4 in SSc lung fibroblasts initiates dedifferentiationKLF4 was overexpressed by adenoviral infection in primary human SSc lung fibroblasts, RNA and protein were extracted, RNA sequencing and differential expression analysis "ad-KLF4 vs ad-Null" were performed to obtain gene and systems level analyses. Markers of alveolar, inflammatory and fibrotic fibroblasts were validated by qPCR and immunoblotting. Our results show that overexpression of KLF4 in SSc fibroblasts initiated dedifferentiation.2026/06/03GSE317058GSM9464487GSM9464486GSM9464489GSM9464488GSM9464490GSM9464492GSM9464491GSM946448534284317058Homo sapiens[42193930]