{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317208/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317208"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Immunomodulation of the prostate tumor microenvironment following inorganic Arsenic exposure","description":"The tumor microenvironment shapes how prostate cancer (PCa) progresses through stromal-immune interactions. We investigated how adipose-derived mesenchymal/stromal cells (ASC) and chronic inorganic arsenic (iAs) exposure jointly influence PCa by using a Ras-driven murine model. ASC-conditioned media enhanced TC2Ras viability, while iAs reversed this effect. In vivo, ASC+iAs tumors showed increased weight, altered immune infiltration, and transcriptomic remodeling, including a sustained IFN-IRF1 axis and immune checkpoint upregulation. ASC-iAs crosstalk promotes immune tolerance, revealing mechanisms by which environmental toxicants modulate cancer immunity.","dates":{"publication":"2026/08/12"},"accession":"GSE317208","cross_references":{"GSM":["GSM9467029","GSM9467038","GSM9467027","GSM9467028","GSM9467032","GSM9467033","GSM9467030","GSM9467031","GSM9467036","GSM9467037","GSM9467034","GSM9467035"],"GPL":["24247"],"GSE":["317208"],"taxon":["Mus musculus"],"PMID":["[41730271]"]}}