GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317208/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317208GEOGSEfalseImmunomodulation of the prostate tumor microenvironment following inorganic Arsenic exposureThe tumor microenvironment shapes how prostate cancer (PCa) progresses through stromal-immune interactions. We investigated how adipose-derived mesenchymal/stromal cells (ASC) and chronic inorganic arsenic (iAs) exposure jointly influence PCa by using a Ras-driven murine model. ASC-conditioned media enhanced TC2Ras viability, while iAs reversed this effect. In vivo, ASC+iAs tumors showed increased weight, altered immune infiltration, and transcriptomic remodeling, including a sustained IFN-IRF1 axis and immune checkpoint upregulation. ASC-iAs crosstalk promotes immune tolerance, revealing mechanisms by which environmental toxicants modulate cancer immunity.2026/08/12GSE317208GSM9467029GSM9467038GSM9467027GSM9467028GSM9467032GSM9467033GSM9467030GSM9467031GSM9467036GSM9467037GSM9467034GSM946703524247317208Mus musculus[41730271]