{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317456/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317456"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell multiomics reveals naïve CD4⁺ T-cell dysregulation in treatment refractory rheumatoid arthritis","description":"Here we determine single-nuclei transcriptional and chromatin landscapes using 10x Genomics Epi Multiome assay on primary CD4+ T-cells isolated from treatment-naïve early RA and refractory (defined as per EULAR definition of difficult-to-treat RA) RA patients. This approach enabled construction of an integrated map of subset-specific immunopathology, comparing rRA with eRA - two opposing ends of the RA disease continuum - to uncover mechanisms underlying treatment refractory disease and inform future therapeutic strategies.","dates":{"publication":"2026/09/14"},"accession":"GSE317456","cross_references":{"GSM":["GSM9472504","GSM9472502","GSM9472503","GSM9472501"],"GPL":["24676"],"GSE":["317456"],"taxon":["Homo sapiens"]}}