GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317456/primary200OKTranscriptomicsHomo sapiens Genome binding/occupancy profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317456GEOGSEfalseSingle-cell multiomics reveals naïve CD4⁺ T-cell dysregulation in treatment refractory rheumatoid arthritisHere we determine single-nuclei transcriptional and chromatin landscapes using 10x Genomics Epi Multiome assay on primary CD4+ T-cells isolated from treatment-naïve early RA and refractory (defined as per EULAR definition of difficult-to-treat RA) RA patients. This approach enabled construction of an integrated map of subset-specific immunopathology, comparing rRA with eRA - two opposing ends of the RA disease continuum - to uncover mechanisms underlying treatment refractory disease and inform future therapeutic strategies.2026/09/14GSE317456GSM9472504GSM9472502GSM9472503GSM947250124676317456Homo sapiens