GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317578/primaryOK200Methylation profilingHomo sapiensMethylation profiling by genome tiling arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317578GEOGSEfalsePediatric and AYA meningiomas constitute a molecularly distinct entity not captured by adult-based risk strategiesMeningiomas in pediatric and adolescent/young adult patients are poorly characterized biologically and clinically, and risk stratification is largely extrapolated from adult tumors. We analyzed 293 tumors from patients aged 0–39 years using integrated histopathological and molecular profiling. Youth-onset meningiomas were enriched for NF2 and SMARCE1 alterations and exhibited a gain-dominated copy-number landscape, including recurrent chr17q gain, whereas canonical adult high-risk features, such as chr1p loss, lacked prognostic significance. Adult-derived prognostic frameworks—including WHO grade, methylation-based stratification, and integrated risk scores—failed to predict progression in patients ≤21 years. Tumors segregated into age-enriched epigenetic clusters defined by SMARCE1, NF2, and BAP1 alterations. Among NF2-altered tumors, patterns of Merlin inactivation shaped by germline status and co-occurring copy-number variations delineated biologically divergent subsets. Across all groups, extent of resection remained the strongest predictor of outcome. These findings define pediatric and young adult meningiomas as a distinct molecular entity requiring age-adapted risk stratification.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 sapiens