{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317679/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317679"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"IkBz target genes in chronic lymphocytic leukemia","description":"IkBz, an atypical IkB protein induced downstream of Toll-like receptors (TLRs) signaling, is pivotal in orchestrating inflammatory responses and inflammation-associated B-cell malignancies. However, the transcriptional and epigenetic programs regulated by IkBz in both normal and malignant B-cells remain poorly described. Here, we analyzed CLL cells by epigenomic profiling to dissect the molecular function of IkBz in leukemia. In primary human B-cells and CLL samples, ChIP-seq and CUT&Tag analyses delineated a comprehensive genome-wide landscape of IkBz binding sites. Key genes, including NFKB2, BATF and FOXP1 gained IkBz binding after TLR stimulation in both CLL and B-cells, whereas CXCR5 was mainly bound in CLL cells. Pharmacological or genetic inhibition of IkBz signaling disrupted the induction of these molecules highlighting its potential role as a central transcriptional tuner that integrates TLR-mediated inflammatory pathways with BCR signaling and migration.","dates":{"publication":"2026/09/17"},"accession":"GSE317679","cross_references":{"GSM":["GSM9476500","GSM9476501","GSM9476502","GSM9476503","GSM9476504","GSM9476505","GSM9476528","GSM9476529","GSM9476498","GSM9476531","GSM9476532","GSM9476499","GSM9476533","GSM9476490","GSM9476491","GSM9476492","GSM9476493","GSM9476494","GSM9476495","GSM9476496","GSM9476497","GSM9476530","GSM9476517","GSM9476518","GSM9476519","GSM9476520","GSM9476487","GSM9476488","GSM9476521","GSM9476489","GSM9476522","GSM9476523","GSM9476524","GSM9476525","GSM9476526","GSM9476527","GSM9476480","GSM9476481","GSM9476482","GSM9476483","GSM9476484","GSM9476485","GSM9476486","GSM9476506","GSM9476507","GSM9476508","GSM9476509","GSM9476476","GSM9476477","GSM9476510","GSM9476478","GSM9476511","GSM9476512","GSM9476479","GSM9476513","GSM9476514","GSM9476515","GSM9476516","GSM9476473","GSM9476474","GSM9476475"],"GPL":["24676"],"GSE":["317679"],"taxon":["Homo sapiens"]}}