{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317692/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317692"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"B cell αv integrin regulates tissue specialization and clonal expansion of lung germinal center and memory B cells after viral infection","description":"Lung-resident B cells are increasingly recognized as key contributors to protective immunity against respiratory viruses, yet the mechanisms that govern their generation and specialization remain poorly understood. Here, we identify B cell-intrinsic αv integrin as a critical negative regulator of germinal center (GC) dynamics and memory B cell formation in the lung following influenza A virus (IAV) infection. Using B cell-specific αv knockout mice, we show that loss of B cell αv integrin leads to persistent GC activity within the inducible bronchus-associated lymphoid tissue and expansion of lung-resident memory B cells, including IgA+ and cross-reactive B cells capable of recognizing heterologous influenza variants. Single-cell transcriptomic and B cell receptor (BCR) sequence analyses reveal that αv restricts clonal expansion and antigenic diversification of GC and memory B cells in the lung, but not in draining lymph nodes, indicating a spatially restricted mechanism of mucosal B cell regulation. These findings position αv integrin as a key checkpoint that constrains local mucosal B cell evolution and suggest new strategies to improve mucosal vaccine efficacy by enhancing GC activity directly in the lung.","dates":{"publication":"2026/05/26"},"accession":"GSE317692","cross_references":{"GSM":["GSM9476720","GSM9476721","GSM9476722","GSM9476723","GSM9476724","GSM9476719"],"GPL":["30172"],"GSE":["317692"],"taxon":["Mus musculus"]}}