GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317736/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317736GEOGSEfalseRNA-seq analysis of rat liver under drug treatmentEpimedii Folium (EF) is widely used in traditional Chinese medicine, yet its hepatotoxic risk is increasingly recognized to be highly context dependent. This study demonstrates that EF induces significant liver injury only under conditions of immune stress, characterized by a pro-inflammatory and metabolically vulnerable hepatic state. Importantly, herb compatibility critically modulates this risk. Co-administration of Psoraleae Fructus (PF) markedly exacerbated EF-induced hepatotoxicity through amplification of inflammatory and cell death–related pathways, whereas Rhizoma Drynariae (RD) partially attenuated liver injury by stabilizing cholesterol and bile acid metabolism and restoring hepatic homeostasis2026/07/26GSE317736GSM9477390GSM9477391GSM9477408GSM9477409GSM9477411GSM9477412GSM9477413GSM9477414GSM9477415GSM9477416GSM9477417GSM9477418GSM9477392GSM9477393GSM9477394GSM9477395GSM9477396GSM9477397GSM9477398GSM9477410GSM9477399GSM9477419GSM9477400GSM9477389GSM9477401GSM9477402GSM9477403GSM9477404GSM9477405GSM9477406GSM9477407GSM9477383GSM9477384GSM9477385GSM9477386GSM9477387GSM9477420GSM947738831008317736Rattus norvegicus