{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317833/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317833"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"PD-1 Deficiency Exacerbates Mycobacterium abscessus Lung Infection via Dysregulated T Cell Responses","description":"A PD-1-deficient Mycobacterium abscessus -infected mouse model was established. The impact of PD-1 on bacterial clearance, immune cell activity, and metabolism was evaluated via colony counting, histopathology, flow cytometry, multiplex immunofluorescence and transcriptomics. We fonud that PD-1−/− mice exhibited increased susceptibility to MAB. Early infection showed elevated lung CD4⁺ T cells, reduced neutrophils, and higher blood cytokines (IFN-γ, IL-21, IL-6, IL-27).","dates":{"publication":"2026/04/14"},"accession":"GSE317833","cross_references":{"GSM":["GSM9479906","GSM9479905","GSM9479908","GSM9479907","GSM9479909","GSM9479898","GSM9479897","GSM9479911","GSM9479899","GSM9479910","GSM9479913","GSM9479912","GSM9479915","GSM9479914","GSM9479894","GSM9479896","GSM9479895","GSM9479917","GSM9479916","GSM9479919","GSM9479918","GSM9479920","GSM9479900","GSM9479922","GSM9479921","GSM9479902","GSM9479901","GSM9479923","GSM9479904","GSM9479903"],"GPL":["34290"],"GSE":["317833"],"taxon":["Mus musculus"]}}