GEOTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317833GEOGSEfalsePD-1 Deficiency Exacerbates Mycobacterium abscessus Lung Infection via Dysregulated T Cell ResponsesA PD-1-deficient Mycobacterium abscessus -infected mouse model was established. The impact of PD-1 on bacterial clearance, immune cell activity, and metabolism was evaluated via colony counting, histopathology, flow cytometry, multiplex immunofluorescence and transcriptomics. We fonud that PD-1−/− mice exhibited increased susceptibility to MAB. Early infection showed elevated lung CD4⁺ T cells, reduced neutrophils, and higher blood cytokines (IFN-γ, IL-21, IL-6, IL-27).2026/04/14GSE317833GSM9479906GSM9479905GSM9479908GSM9479907GSM9479909GSM9479898GSM9479897GSM9479911GSM9479899GSM9479910GSM9479913GSM9479912GSM9479915GSM9479914GSM9479894GSM9479896GSM9479895GSM9479917GSM9479916GSM9479919GSM9479918GSM9479920GSM9479900GSM9479922GSM9479921GSM9479902GSM9479901GSM9479923GSM9479904GSM947990334290317833Mus musculus