{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317911/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317911"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"GPR56 as a Key Modulator of the Androgen-Responsive Transcriptome in Prostate Cancer Cells","description":"To investigate the role of GPR56 in androgen-mediated gene regulation, RNA sequencing was performed in LNCaP (prostate cancer cells) wild-type or GPR56-knockdown (LNCaP cells transfected with GPR56 siRNA, GPR56-KD), following testosterone stimulation. Transcriptomic analysis revealed extensive androgen-responsive gene expression in LNCaP-WT cells, including established androgen target genes, which was markedly reduced upon GPR56 knockdown. These findings suggest that GPR56 is required for optimal androgen response of androgen-dependent transcriptome in prostate cancer cells.","dates":{"publication":"2026/04/12"},"accession":"GSE317911","cross_references":{"GSM":["GSM9481834","GSM9481835","GSM9481836","GSM9481826","GSM9481837","GSM9481830","GSM9481831","GSM9481832","GSM9481833","GSM9481827","GSM9481828","GSM9481829"],"GPL":["16791"],"GSE":["317911"],"taxon":["Homo sapiens"]}}