GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317911/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317911GEOGSEfalseGPR56 as a Key Modulator of the Androgen-Responsive Transcriptome in Prostate Cancer CellsTo investigate the role of GPR56 in androgen-mediated gene regulation, RNA sequencing was performed in LNCaP (prostate cancer cells) wild-type or GPR56-knockdown (LNCaP cells transfected with GPR56 siRNA, GPR56-KD), following testosterone stimulation. Transcriptomic analysis revealed extensive androgen-responsive gene expression in LNCaP-WT cells, including established androgen target genes, which was markedly reduced upon GPR56 knockdown. These findings suggest that GPR56 is required for optimal androgen response of androgen-dependent transcriptome in prostate cancer cells.2026/04/12GSE317911GSM9481834GSM9481835GSM9481836GSM9481826GSM9481837GSM9481830GSM9481831GSM9481832GSM9481833GSM9481827GSM9481828GSM948182916791317911Homo sapiens