GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317955/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317955GEOGSEfalsePD-1 Deficiency Exacerbates Mycobacterium abscessus Lung Infection via Metabolic Rewiring and Dysregulated Neutrophil ResponsesA PD-1-deficient MAB-infected mouse model was established. The impact of PD-1on bacterial clearance, immune cell activity, and metabolism was evaluated via colony counting, histopathology, flow cytometry, multiplex immunofluorescence, transcriptomics, and metabolic profiling. PD-1−/− mice exhibited increased susceptibility to MAB. Late infection featured further Th1 decline, neutrophil rise, and enhanced glycolysis. Peripheral blood displayed lower CXCL9 but elevated IL-6, IL-21, IL-27, CXCL2, CXCL10, and S100A8 production.2026/04/14GSE317955GSM9483554GSM9483553GSM9483564GSM9483556GSM9483555GSM9483550GSM9483561GSM9483560GSM9483563GSM9483552GSM9483562GSM9483551GSM9483558GSM9483557GSM948355934290317955Mus musculus