{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317978/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317978"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The role of BAF60C in type 2 diabetes——RNAseq","description":"This research identify reduced expression of BAF60C in diabetic islets and demonstrate that altered β-cell BAF60C levels strongly influence metabolic homeostasis. Genetic loss of BAF60C in β-cells exacerbates hyperglycemia and islet dysfunction under metabolic stress, whereas β-cell–specific restoration of BAF60C produces protective effects. These findings establish BAF60C as an important regulator of β-cell integrity and disease progression in T2D.","dates":{"publication":"2026/02/06"},"accession":"GSE317978","cross_references":{"GSM":["GSM9483790","GSM9483796","GSM9483795","GSM9483798","GSM9483797","GSM9483792","GSM9483791","GSM9483794","GSM9483793","GSM9483804","GSM9483803","GSM9483806","GSM9483805","GSM9483800","GSM9483789","GSM9483788","GSM9483802","GSM9483801","GSM9483807","GSM9483785","GSM9483784","GSM9483787","GSM9483786","GSM9483783","GSM9483799"],"GPL":["23479"],"GSE":["317978"],"taxon":["Mus musculus"]}}