GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317978/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317978GEOGSEfalseThe role of BAF60C in type 2 diabetes——RNAseqThis research identify reduced expression of BAF60C in diabetic islets and demonstrate that altered β-cell BAF60C levels strongly influence metabolic homeostasis. Genetic loss of BAF60C in β-cells exacerbates hyperglycemia and islet dysfunction under metabolic stress, whereas β-cell–specific restoration of BAF60C produces protective effects. These findings establish BAF60C as an important regulator of β-cell integrity and disease progression in T2D.2026/02/06GSE317978GSM9483790GSM9483796GSM9483795GSM9483798GSM9483797GSM9483792GSM9483791GSM9483794GSM9483793GSM9483804GSM9483803GSM9483806GSM9483805GSM9483800GSM9483789GSM9483788GSM9483802GSM9483801GSM9483807GSM9483785GSM9483784GSM9483787GSM9483786GSM9483783GSM948379923479317978Mus musculus