GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318028/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318028GEOGSEfalsePharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficitsEarly life adversity (ELA) is a major risk factor for psychiatric disorders, but targeted preventative strategies are lacking due to poor mechanistic insight. The FKBP51 protein, a co-chaperone of the glucocorticoid receptor, is a key mediator of stress vulnerability. We tested if pharmacological inhibition of FKBP51 with the selective inhibitor SAFit2 prevents the long-term consequences of ELA. Mice exposed to ELA exhibited persistent deficits in social behavior, manifesting as social subordination in adolescence and adulthood. Early-life SAFit2 treatment fully rescued these ELA-induced behavioral impairments. Transcriptional profiling across six stress-relevant brain regions revealed that SAFit2 normalized ELA-driven gene expression changes, particularly in the medial prefrontal cortex and nucleus accumbens. Functional analysis showed the rescue converged on immunoregulatory and neuroactive ligand-receptor signaling pathways. Our findings establish FKBP51 as a critical pharmacological target for reversing the lasting impact of early life adversity on brain function, offering a path toward preventative treatment for ELA-related psychopathology.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 musculus[42263247]