{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318184/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318184"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Translatome profiling by parallel RNA-seq and Ribo-seq during DUX-induced reprogramming of mouse embryonic stem cells to a totipotent-like state.","description":"This dataset contains parallel RNA sequencing (RNA-seq) and ribosome profiling (Ribo-seq) data from mouse embryonic stem cells (mESCs) undergoing DUX-induced reprogramming toward a 2-cell-like cell (2CLC) state. Samples were collected at three critical time points: 0 hours, 12 hours, and 24 hours post-induction. The data capture the dynamic landscape of both transcript abundance and genome-wide translational activity throughout this cell fate transition. The dataset enables analysis of: 1) Transcriptional changes and translation efficiency (TE) calculations; 2) Identification of genes regulated specifically at the translational level; 3) The relationship between the in vitro reprogramming translatome and in vivo embryonic development stages. Our analyses revealed a profound but transient suppression of global translation during early reprogramming, coupled with a selective upregulation of mitochondrial genome-encoded transcripts at the translational level. These data provide a comprehensive resource for studying translational control mechanisms in cellular reprogramming and early embryogenesis.","dates":{"publication":"2026/09/23"},"accession":"GSE318184","cross_references":{"GSM":["GSM9488773","GSM9488772","GSM9488771","GSM9488770","GSM9488769","GSM9488768","GSM9488767","GSM9488766","GSM9488765","GSM9488776","GSM9488775","GSM9488774"],"GPL":["24247"],"GSE":["318184"],"taxon":["Mus musculus"],"PMID":["[42617736]"]}}