{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318188/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318188"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"GDF15 impacts chronic kidney disease and associated cachexia through distinct mechanisms","description":"Chronic kidney disease (CKD) is frequently accompanied by cachexia and substantial metabolic alterations, including anorexia, muscle/fat wasting, and inflammation, which collectively contribute topoor clinical outcomes.However, the underlying molecular mechanisms remain poorly understood. This study demonstrates that growth differentiation factor 15 (GDF15) plays a pivotal role in CKD-associated cachexia and molecular changes.","dates":{"publication":"2026/09/10"},"accession":"GSE318188","cross_references":{"GSM":["GSM9488803","GSM9488802","GSM9488801","GSM9488800","GSM10042233","GSM10042234","GSM10042235","GSM10042236","GSM10042237","GSM10042238","GSM10042239","GSM9488795","GSM9488811","GSM9488810","GSM9488799","GSM9488798","GSM9488797","GSM9488796","GSM10042244","GSM9488809","GSM9488808","GSM9488807","GSM10042240","GSM10042241","GSM9488806","GSM10042242","GSM9488805","GSM9488804","GSM10042243"],"GPL":["34290"],"GSE":["318188"],"taxon":["Mus musculus"]}}