{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318190/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Drosophila melanogaster"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318190"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The E-cadherin-Wnt-mir-994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance","description":"E-cadherin is encoded by the shg gene and is also expressed in Drosophila ovarian IGS cells. Its knockdown leads to a reduction in GSCs. To investigate the downstream molecular mechanisms and changes in gene expression, we labeled IGS cells with GFP, sorted GFP-positive cells one week after shg knockdown, and performed RNA sequencing. Finally, differential gene expression analysis along with GO and KEGG analyses were conducted.","dates":{"publication":"2026/07/08"},"accession":"GSE318190","cross_references":{"GSM":["GSM9489033","GSM9489032","GSM9489031","GSM9489030","GSM9489029","GSM9489028"],"GPL":["13304"],"GSE":["318190"],"taxon":["Drosophila melanogaster"],"PMID":["[42359497]"]}}