GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318208/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318208GEOGSEfalseRNA-seq of a Leigh Syndrome patient blood being treated with Omaveloxolone.A male patient diagnosed with Leigh Syndrome due to a compound heterizygous mutation in SURF1 (SURF1 c.312_321del10insAT (p.Leu105*); SURF1 c.574C>T (p.Arg192Trp)) was prescribed Omaveloxolone under physican supervision. Pre-treatment patient blood showed deficiency in pathways associated with oxidative phosphorylion and cellular energetics. Omaveloxolone normalized this phenotype via enrichment of these pathways.2026/08/01GSE318208GSM9489301GSM9489312GSM9489311GSM9489310GSM9489309GSM9489308GSM9489307GSM9489306GSM9489305GSM9489304GSM9489303GSM9489314GSM9489313GSM948930234284318208Homo sapiens