GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318387/primaryOK200Methylation profilingHomo sapiensMethylation profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318387GEOGSEfalsePromoter hypomethylation of cadherin-7: a novel epigenetic marker associated with cerebral small vessel diseaseIntroduction: Cerebral small vessel disease (SVD), manifesting as white matter hyperintensities (WMH), lacunar infarctions, and cerebral microbleeds on MRI, has been linked to epigenetic alterations. Methods: Genome-wide promoter methylation was profiled using the Infinium MethylationEPIC v2.0 array in peripheral inflammatory cells from 16 patients without SVD and 16 patients with all three imaging features. Results: EPIC profiling identified 17 promoter regions with significant differences between groups, and CDH7 hypomethylation emerged as an independent predictor of SVD imaging features. Conclusion: CDH7 hypomethylation was identified and validated as an epigenetic marker predictive of MRI-defined SVD imaging features.2026/04/01GSE318387GSM9493614GSM9493613GSM9493612GSM9493611GSM9493618GSM9493617GSM9493616GSM9493615GSM9493619GSM9493620GSM9493603GSM9493602GSM9493601GSM9493589GSM9493600GSM9493607GSM9493606GSM9493605GSM9493604GSM9493609GSM9493608GSM9493591GSM9493590GSM9493595GSM9493594GSM9493593GSM9493592GSM9493610GSM9493599GSM9493598GSM9493597GSM949359633022318387Homo sapiens[41890232]